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Self (autologous) stem cell transplants

This page is about stem cell transplants that use your own stem cells (autologous stem cell transplants). Most stem cell transplants for lymphoma are autologous transplants. We have separate information on stem cell transplants using stem cells from a donor (allogeneic stem cell transplants).

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What is a 'self' (autologous) stem cell transplant?

Who might have one?

What does it involve?

What are the risks?



What is 'self' (autologous) stem cell transplant and when is it done?

A stem cell transplant is a procedure that replaces damaged or destroyed stem cells (cells in your bone marrow that make new blood cells) with healthy stem cells. ‘Autologous’ means something that comes from you, as opposed to something that comes from someone else. It is sometimes called an ‘autograft’.

If you have lymphoma, you might have a stem cell transplant if you need high-dose anti-cancer treatment. High-dose treatment aims to destroy the lymphoma cells but it also destroys your stem cells. This stops you making new blood cells. A stem cell transplant allows you to have high-dose treatment and still be able to make new blood cells.

A stem cell transplant is an intensive form of treatment. It can take many months to fully recover afterwards.

Watch Hannah share her experience of an autologous stem cell transplant.

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Who might have an autologous stem cell transplant?

Most people with lymphoma do not need a stem cell transplant. Autologous stem cell transplants are used in certain circumstances with the aim of curing your lymphoma (especially Hodgkin lymphoma or high-grade non-Hodgkin lymphoma) or making your remission from lymphoma last longer than would otherwise be possible.

A stem cell transplant is an intensive form of treatment and you have to be well enough to have one. It can take many months to fully recover. Your medical team consider many factors before recommending a stem cell transplant. Below we list some of the situations when an autologous stem cell transplant might be recommended. Not everybody with these types of lymphoma needs a stem cell transplant – and there might be other situations where your medical team feel a stem cell transplant is the best option for you.

You might have an autologous stem cell transplant:

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What does an autologous stem cell transplant involve?

In an autologous stem cell transplant:

  • you have tests and scans to make sure you are well enough to have the treatment
  • your own, healthy stem cells are collected from your blood and stored
  • you have high-dose anti-cancer treatment in hospital (this is also called ‘conditioning treatment’)
  • your stored stem cells are given back to you to replace the stem cells that have been destroyed by the high-dose anti-cancer treatment
  • you stay in hospital while you wait for your blood counts to recover.

We have detailed information about each step on our page on having a stem cell transplant.

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What are the risks?

The most serious risks of autologous stem cell transplants are:

Risk of infection

After an autologous stem cell transplant, you have very low blood counts for a few weeks. Having a low white blood cell count, especially a type of blood cell called ‘neutrophils’ (neutropenia), puts you at very high risk of developing an infection. Your blood counts start to rise after a few weeks but it can take many months for your immune system to recover.

While you are in hospital, your medical team take precautions to reduce your risk of infection. They also monitor you closely for any signs of infection. Although taking precautions can reduce your risk of infection, you cannot avoid all sources of infection. Infections can be treated, particularly if they are caught early.

When you go home, your medical team should tell you what signs to look out for and who to contact if you are worried you might have an infection.

Contact your medical team immediately if you have any signs of infection.

I felt nervous about leaving the hospital environment where I had been in isolation with people gowned up to protect me from germs. Now I was going home and in reality it was once I had got home that the recovery started and I could take my own steps to avoid infection. 

Jamie, who was diagnosed with Hodgkin lymphoma and had an ASCT

Side effects of conditioning treatment

You are likely to experience side effects from your high-dose anti-cancer treatment (‘conditioning’ treatment). We have separate information on the most common side effects of lymphoma treatments, including practical tips on how to cope with them. You might find the following pages particularly helpful:

I began to feel better, but it was slow and not every day was better than the last. There were times I felt I was going backwards and my energy levels weren’t getting any higher. But I was getting better and I just needed to be patient.

Owen, who was diagnosed with angioimmunoblastic T-cell lymphoma and had an ASCT.

Graft failure

Graft failure occurs if the transplanted stem cells fail to settle in your bone marrow and make new blood cells. This means your blood counts do not recover. Graft failure is serious but it is very rare after an autologous stem cell transplant. Your medical team monitors your blood counts closely. If your graft does fail, you might be treated initially with growth factors or hormones. These encourage the stem cells in your bone marrow to produce more cells. You might need a second stem cell transplant.

Late effects

Late effects are health problems that may develop months or years after your lymphoma treatment. Most transplant centres have dedicated late effects services that offer screening programmes to detect late effects as early as possible. This gives you the best chance of being treated successfully if you develop any late effects.

Your medical team should tell you what late effects you may be at risk from and what you can do to reduce your risk of developing them. For more information, see our page on late effects of lymphoma treatment.

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Follow-up after an autologous stem cell transplant

Most people go home 2 to 3 weeks after having their stem cell transplant. However, it can be longer, particularly if you develop a serious infection or other complications. Your risk of complications is highest in the first few weeks after your transplant but it can take many months for your blood counts to build up to normal levels. 

After you go home, you are usually seen in the clinic every week at first to check your blood counts are recovering well. You might need blood transfusions if they are low.

You then have appointments each month. Around 3 months after your transplant you are likely to have a CT scan or PET/CT scan to see how the lymphoma has responded to the treatment. If you had lymphoma in your bone marrow, you might also have a bone marrow biopsy.

You have regular tests to check on your recovery. Gradually, you are seen less often. Your follow-up appointments are to check that your lymphoma has not come back (relapsed) and to look out for late effects (side effects that develop months or years after treatment).

When you have a stem cell transplant, you lose your immunity to diseases you were vaccinated against before your transplant. This includes the vaccinations you had as a child. Around 6 months to a year after your transplant, you might be offered a revaccination programme. You should also have the annual winter flu jab and the pneumococcal pneumonia vaccination.

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Recovery after an autologous stem cell transplant

Although you might be allowed home a couple of weeks after an autologous stem cell transplant, it takes 3 to 6 months for you to recover completely. This can be a difficult time physically and emotionally. You might find our information on living with and beyond lymphoma helpful. 

I was back to work five days a week, but realised I was struggling. I felt very tired and had some digestive problems and also could not achieve the closure to my lymphoma experience I wanted. I realised I needed to adjust my work life balance.

Owen, who was diagnosed with angioimmunoblastic T-cell lymphoma and had an ASCT.

When you first go home, your blood counts are likely to be low. Follow any precautions your medical team recommend to help you stay well.

You are also likely to be experiencing side effects from your high-dose treatment. You may feel unwell and very tired. Give yourself time to recover. Many people feel well enough to return to work between 3 and 6 months after their transplant. You may find it helpful to start with shorter days or weeks and gradually build them up as you feel able to.

Your medical team should advise you on other factors to consider during your recovery. 

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Listen to our podcast where John Murray, Nurse Clinician in Bone Marrow Transplant, and Angie Leather, who is Lead Nurse for Transplant and Haematology CNS, talk about the role of stem cell transplants, when they are used and the important differences between autologous (self) and allogeneic (donor) stem cell transplants. This podcast includes discussions around this often very difficult subject, and contains information on side effects and treatment outcomes that may be potentially distressing.

Further reading