Chemotherapy regimens for lymphoma

Chemotherapy drugs for lymphoma are usually given as a ‘regimen’, a treatment plan that includes more than one type of drug. We have separate information about how chemotherapy works, the ways it’s given and its possible side effects.

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What is a chemotherapy regimen?

Why is chemotherapy given as a regimen?

Common chemotherapy regimens for lymphoma

Frequently asked questions

What is a chemotherapy regimen?

A chemotherapy regimen is a treatment plan that usually involves more than one drug. The regimen sets out:

  • the name of the drugs
  • the dose of each drug
  • how often you take the drugs
  • how the drugs are given
  • how long you take each drug for.

Most regimens are given as a block of chemotherapy followed by a rest period to allow your body to recover. This is known as a ‘cycle’. Cycles often last between 2 and 4 weeks. A whole course of treatment can vary from a number of weeks to months.

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Why is chemotherapy given as a regimen?

Some chemotherapy drugs are given on their own. Examples include pixantrone and bendamustine. You might have a single chemotherapy drug if the aim is to control symptoms of lymphoma, rather than to treat the lymphoma itself.

Often, however, a combination of chemotherapy drugs are given to treat lymphoma. Each drug works in a slightly different way to kill the lymphoma cells. Together, the drugs are able to kill more of the lymphoma than if you have them alone. You might be interested in our animation video that explains how chemotherapy works.

Chemotherapy drugs are also sometimes given with a different type of drug, such as an antibody therapy like rituximab, a targeted drug like ibrutinib, or a steroid such as prednisolone.

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Common chemotherapy regimens for lymphoma

There are lots of different chemotherapy regimens. Below, we list regimens that are most commonly used for lymphoma. Don’t worry if your regimen isn’t listed here; your doctors plan the best treatment for you and new regimens become available as they are approved.

The names of chemotherapy regimens are usually acronyms, made up of the first letters of each of the drugs they contain. Sometimes, to make them easier to say, a regimen uses a drug’s ‘trade’ or brand name (the name the pharmaceutical company gives the drug). Trade names start with a capital letter and sometimes have a registered trademark (®).

Some chemotherapy regimens have names that don’t use acronyms. These include bendamustine and chlorambucil, which are sometimes given with rituximab to treat some types of lymphoma.

For some types of lymphoma, other drugs are given either alone or with chemotherapy. This is sometimes the case with:

  • targeted drugs, such as ibrutinib
  • antibody therapies, such as rituximab.

When rituximab is given alongside a chemotherapy regimen, an ‘R’ is added to the name. Examples include R-CHOP, R-ICE, R-CVP and R-bendamustine. Rituximab is usually used only for B-cell non-Hodgkin lymphomas.

Acronyms for chemotherapy regimens sometimes used to treat lymphoma

ABVD – doxorubicin (Adriamycin®), bleomycin, vinblastine and dacarbazine

BEACOPPbleomycin, etoposide, doxorubicin (Adriamycin®), cyclophosphamide, vincristine (Oncovin®), procarbazine and prednisolone; a higher-dose regimen is sometimes called BEACOPPesc (escalated dose)

BEAM – carmustine (BiCNU®), etoposide, cytarabine (Ara-C) and melphalan

CHEOPcyclophosmamide, doxorubicin (or hydroxydaunorubicin), etoposide, vincristine (Oncovin®) and prednisolone

ChlVPPchlorambucil, vinblastine, procarbazine and prednisolone

CHOPcyclophosphamide, doxorubicin (or hydroxydaunorubicin), vincristine (Oncovin®) and prednisolone

CHVPicyclophosphamide, doxorubicin (or hydroxydaunorubicin), etoposide (Vepesid®), prednisolone and interferon-alfa

CODOX-Mcyclophosphamide, vincristine (Oncovin®), doxorubicin and methotrexate

CVPcyclophosphamide, vincristine and prednisolone

DA-EPOCHdose-adjusted etoposide, prednisolone, vincristine (Oncovin®), cyclophosphamide and doxorubicin (or hydroxydaunorubicin)

DHAPdexamethasone, high-dose cytarabine (Ara-C) and cisplatin (Platinol®)

ESHAPetoposide, methylprednisolone (Solu-Medrone®), high-dose cytarabine (Ara-C) and cisplatin (Platinol®)

FCfludarabine and cyclophosphamide

GCVPgemcitabine, cyclophosphamide, vincristine and prednisolone

GDPgemcitabine, dexamethasone and cisplatin (Platinol®)

GEMOXgemcitabine and oxaliplatin

GEM-Pgemcitabine, cisplatin and methylprednisolone

Hyper-CVADcyclophosphamide, vincristine, doxorubicin (Adriamycin®) and dexamethasone; ’hyper’ is short for ‘hyperfractionated’, which means that you have the same drug more than once in a day 

ICEifosfamide, carboplatin and etoposide

IGEVifosfamide, gemcitabine and vinorelbine

IVACifosfamide, etoposide (VP-16) and cytarabine (Ara-C)

Maxi-CHOPmaximum dose cyclophosphamide, doxorubicin (or hydroxydaunorubicin), vincristine (Oncovin®) and prednisolone 

MCPmitoxantrone, chlorambucil and prednisolone

P-MitCEBOprednisolone, mitoxantrone, cyclophosphamide, etoposide, bleomycin and vincristine (Oncovin®)

Macmillan Cancer Support has an online tool where you can search for a chemotherapy regimen and find out more about it.

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Frequently asked questions about chemotherapy

Which regimen will I have?

The regimen you have depends on a number of factors including:

  • the type of lymphoma you have
  • how quickly the lymphoma is growing – whether it’s fast-growing (high-grade) or slow-growing (low-grade)
  • where in your body the lymphoma is
  • the symptoms or problems your lymphoma is causing
  • whether you have previously had other treatments for lymphoma
  • whether or not you have other health conditions and whether you’re on other medication
  • your age, general health and fitness.

Your medical team will talk to you about the best treatment for you based on your individual circumstances.

How will I know if the treatment is working?

Once you’ve had a few cycles of treatment, you’ll have tests and scans to see if the treatment is working. In some cases, your medical team might recommend changes to your treatment plan, for example:

  • increasing or decreasing the dose of chemotherapy drugs
  • changing one or more of the chemotherapy drugs in the regimen.

What side effects will I have?

Treatment affects each person differently – even if you have the same treatment as someone else, you might experience different side effects. Your doctor, clinical nurse specialist or chemotherapy nurse should speak to you about any side effects and late effects you might expect from your chemotherapy regimen. 

Macmillan Cancer Support’s online tool lists common side effects of different chemotherapy regimens.

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Further reading

Related content

Cancer Research UK

You can use Cancer Research UK’s online ‘cancer drugs A to Z list’ to find out about individual drugs, drug combinations and their side effects.

Macmillan Cancer Support

Macmillan Cancer Support has an online tool where you can search for a chemotherapy regimen and find out more about it.