New treatment for skin lymphoma not to be available on the NHS in England and Wales

NICE is not recommending mogamulizumab for the treatment of relapsed or refractory mycosis fungoides or Sézary syndrome.

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The National Institute for Health and Care Excellence (NICE) has today announced that it is not recommending mogamulizumab for the treatment of people with mycosis fungoides or Sézary syndrome. These are the two most common subtypes of cutaneous T-cell lymphoma, rare types of non-Hodgkin lymphoma that affect the skin.

People who were already being treated with mogamulizumab on the NHS before the NICE guidance was published can continue with their treatment.

Mogamulizumab is an antibody therapy that is licensed for adults with mycosis fungoides or Sézary syndrome who have received at least one previous systemic therapy. 

NICE decided that the evidence supporting mogamulizumab was not strong enough to be certain that it is cost-effective compared to standard treatments for people with T-cell skin lymphoma in the UK. The clinical trial that formed the basis for mogamulizumab’s licence compared mogamulizumab to a treatment that is not available in the UK so NICE could not make a direct comparison and felt that indirect comparisons were insufficient.

Lymphoma Action, along with other organisations and individuals, appealed against NICE’s preliminary decision not to recommend the treatment but, unfortunately, the appeal was not successful.
 

 
We are deeply disappointed by this decision and the effect it will have on people living with these rare and debilitating haematological cancers. We know that there is a real need for effective treatments for people living with mycosis fungoides and Sézary syndrome as there are currently limited treatment options and this can have a significant impact on a person’s quality of life, daily function and social interactions. We believe patients should have access to the best care and there continues to be a need for effective treatments for people living with mycosis fungoides and Sézary syndrome. We call on the relevant stakeholders, NICE and the company, to continue to discuss the options and to work with the patient community to find a resolution.
Stephen Scowcroft, Director of Operations and External Affairs at Lymphoma Action

Mogamulizumab is currently being assessed for NHS use in Scotland. Northern Ireland usually follows NICE recommendations.

Find out more about drug development, approval and funding, or visit Lymphoma TrialsLink for the latest on clinical trials for lymphoma.

4 March 2021