MAST: A trial investigating the link between gut health and stem cell transplant outcomes in patients with chronic lymphocytic leukaemia

This trial aims to see whether improving gut microbiota to healthier levels can improve outcomes in patients with chronic lymphocytic leukaemia (CLL) having stem cell transplants.

You can share the following ClinicalTrials.gov Identifier with your medical team so they can find out more about the trial: ISRCTN13241761 

Trial aim and background  

The aim of this trial is to investigate the ability to improve gut microbiota to healthier levels, and whether this improves clinical outcomes after a stem cell transplant. It will also look at how well tolerated and acceptable intestinal microbiota transplant (IMT) is, how effective they are at altering the gut microbiome, and markers of health including admission to intensive care unit, fever and incidence of graft-versus-host disease.

One group of patients will be given a capsule intestinal microbiota transplant, while the other group will be given a placebo. You cannot chose which group, this will be done randomly.  

Who can enter 

Adults with blood cancers including CLL who are deemed fit for allogenic stem cell transplant may be eligible for this trial.

Locations 

Recruitment is taking place in the following UK locations:

  • Hammersmith Hospital, London
  • The Royal Marsden Hospital, London
  • University College London Hospital, London
  • United Leeds Teaching Hospital NHS Trust, Leeds
  • Queen Elizabth Hospital, Birmingham
  • Kings College Hospital, London
     

Further information 

More information about what treatments are involved, the criteria you must meet in order to take part in the trial and where this trial is taking place are available at: https://www.isrctn.com/ISRCTN13241761

Lymphoma Action are not able to refer people to specific trials. If you are interested in taking part in this trial we recommend that you print the trial summary and discuss it with your medical team. They can advise you on whether you might be eligible for the trial and how you can take part based on your individual circumstances.