BOOST: studying samples from stem cell transplant donors and recipients to improve transplant success rates and reduce side effects

This trial is looking at ways that the success of stem cell transplants can be improved. No treatment is given this study, people are asked to give blood samples for research.

Trial aim and background  

The aim of this study is to improve success rates and reduce side effects of stem cell transplants. 

The researchers are studying blood samples of people having transplants and their stem cell donors to learn more about:

  • the transplant process
  • what influences success of the treatment
  • why side effects happen in some people and not others.

People will give 2 blood samples before they have their transplant. At the same time the donor (if there is one) also gives a blood sample when they come in to donate their stem cells.

After the transplant, blood samples are also taken:

  • once a week for the first 4 weeks
  • every 2 weeks for 20 weeks
  • after 20 weeks, once a month for the following year
  • then once every 3 months for the next 2 ½ years.

If there is a donor transplant, more blood samples are taken if:

  • people develop a complication called graft versus host disease
  • people get infected with cytomegalovirus (CMV) or Epstein-Barr virus (EBV)
  • people have extra white blood cell transfusions from their donor.

Who can enter

People over 16 who are having a stem cell transplant at Queen Elizabeth Hospital, Birmingham may be eligible for this trial

Locations

Recruitment is taking place at the Queen Elizabeth Hospital, Birmingham

Further information

More information about what treatments are involved, the criteria you must meet in order to take part in the trial and where this trial is taking place are available at: Cancer Research UK

Lymphoma Action are not able to refer people to specific trials. If you are interested in taking part in this trial we recommend that you print the trial summary and discuss it with your medical team. They can advise you on whether you might be eligible for the trial and how you can take part based on your individual circumstances.