BOOST: studying samples from stem cell transplant donors and recipients to improve transplant success rates and reduce side effects

There is no treatment in this study. You are asked to give blood samples for research.


Purpose of study

The aim of this study is to improve success rates and reduce side effects of stem cell transplants

The researchers are studying blood samples of people having transplants and their stem cell donors to learn more about:

  • the transplant process
  • what influences success of the treatment
  • why side effects happen in some people and not others.

What is involved

You give 2 blood samples before you have your transplant. Your donor (if you have one) also gives a blood sample when they come in to donate their stem cells.

After your transplant, you give blood samples:

  • once a week for the first 4 weeks
  • every 2 weeks for 20 weeks
  • after 20 weeks, once a month for the following year
  • then once every 3 months for the next 2 ½ years.

If you have a donor transplant, you have more blood samples taken if:

  • you develop a complication called graft versus host disease
  • you get infection with cytomegalovirus (CMV) or Epstein-Barr virus (EBV)
  • you have extra white blood cell transfusions from your donor.

Who can enter

Your consultant can give you advice on whether this trial might be suitable for you.

Up to 500 people are needed for this trial.

You may be able to enter if:

  • You have a lymphoma that needs to be treated with a stem cell transplant.
  • You are willing and able to give informed consent.
  • You are 16 or over.

You will not be able to enter if:

  • You don’t meet the inclusion criteria.

Further information

More information about this trial is available at Cancer Research UK.