Targeted radiotherapy for SCT: a phase 1 / 2 trial to see if radiotherapy to the bone marrow is safe before an allogeneic stem cell transplant and whether it can improve its success

This trial is now closed. It is no longer recruiting participants.

Purpose of trial

The aim of the trial is to see if it is safe and helpful to give targeted radiotherapy as part of an allogeneic stem cell transplant for several different types of cancer, including lymphoma.

Before having an allogeneic stem cell transplant, some people might have external beam radiotherapy to the whole body. This kills cancer cells in the bone marrow and makes room for the new stem cells to settle in the bone marrow and start to divide and grow.

Sometimes, cancer cells are left in the bone marrow after this treatment, which causes the cancer to come back (relapse). Increasing the dose of external radiotherapy can help to stop this, but can also have life-threatening side effects. In this trial, the researchers want to see if radiotherapy to the bone marrow alone can be safer and more effective.


As part of the treatment before your stem cell transplant (conditioning), you have radiotherapy with a radioactive molecule attached to an antibody (yttrium90 attached to an anti-CD66 antibody). The antibody should carry the radiation directly to the bone marrow and kill lymphoma cells and bone marrow cells without delivering high doses of radiation to any other body tissues.

Five days before this treatment, you have a test dose of a similar radioactive molecule called irridium111. You then have 4 CT scans over the next 5 days. This helps the doctors to work out the dose of yttrium90 that you need and make sure this is the right treatment for you.

Who can enter

Your consultant can give you advice on whether this trial might be suitable for you.

Around 55 people are needed for this trial.

You may be able to enter if:

  • You have been diagnosed with lymphoma and are to be treated with an allogeneic stem cell transplant.
  • You have not had chemotherapy to treat your lymphoma in the 3 weeks before joining the trial.
  • You are well enough to look after yourself and are up and about more than 50% of your waking hours, even if you are not well enough to work.
  • Your blood and other health test results are satisfactory.
  • You are between 18 and 75 years old.

You will not be able to enter if:

  • You have any health problems that your doctor thinks might make it unsafe for you to have the trial treatment.
  • You have had asthma or eczema caused by an allergy.
  • You have ever had a severe allergic reaction to penicillin or streptomycin.
  • You are pregnant.

Further information

More information about this trial is available at