NF-kB in CLL: a study looking at a signalling pathway in blood samples of people with chronic lymphocytic leukaemia (CLL)

There are no treatments in this study. The researchers need permission to use your blood samples for research.


Purpose of study

The aims of this study are to:

  • find out more about the role of the NF-kB pathway in keeping chronic lymphocytic leukaemia (CLL) cells alive
  • look at the effects of treatments for CLL on the NF-kB pathway
  • identify new drugs that can block this pathway and cause CLL cells to die.

What is involved

You are asked for permission for your blood samples to be used for research.

You don’t need to go to the hospital for extra tests – blood for the study is taken from the blood tests that are part of your regular treatment and follow-up.

The researchers record only your age, sex and details of any treatment you have had.


Who can enter

Your consultant can give you advice on whether this trial might be suitable for you. 

The researchers are looking for around 400 people to take part.

You may be able to enter if:

  • You have chronic lymphocytic leukaemia (CLL).
  • Your lymphoma is untreated or you have received previous treatment but your lymphoma did not respond or has come back after treatment.
  • You are attending a CLL clinic in Cardiff.
  • You are 18 or over.

You will not be able to enter if:

  • You are known to have HIV, hepatitis or another infectious disease that could be passed to laboratory staff.