Purpose of study
The aim of this research study is to find markers that identify whether people have slow-growing or fast-growing mantle cell lymphoma when they are diagnosed.
In this study, researchers collect samples from people with mantle cell lymphoma when they are diagnosed. They look at what happens to these people throughout their treatment to find out if they have the slow-growing or fast-growing form. Once they know whether a participant has the slow growing or fast growing form of mantle cell lymphoma, the researchers can then try to find genetic and biological markers from their samples.
Accurate diagnosis is important in making sure people get the most appropriate treatment possible.
Doctors know that most people with mantle cell lymphoma need intensive chemotherapy. However, some people have a slow-growing form and may not have symptoms or may need treatment for years after diagnosis. The latter group can be monitored by their doctors until they need treatment. This is called active monitoring. Currently, doctors can’t identify the slow-growing form of mantle cell lymphoma when people are first diagnosed.
What is involved
There are no treatments in this study. You are asked to give:
- saliva and blood samples when you are diagnosed with mantle cell lymphoma
- samples of the tumour tissue removed when you have a biopsy.
Afterwards, the researchers collect information about what happens to you as you go through your treatment and follow-up (check-up appointments after your treatment). This information is collected from your medical notes. Your information is kept confidential – ask the study organisers how they do it and who has access to your information.
Who can enter
Your consultant can give you advice on whether this trial might be suitable for you.
Around 300 people are needed for this trial.
You may be able to enter if:
- You have recently been diagnosed with mantle cell lymphoma
- You are over 16.
You will not be able to enter if:
- You have any other type of lymphoma
- You have already had any treatment for your mantle cell lymphoma.
More information about this trial is available at Cancer Research UK.