Purpose of study
The aim of the study is to learn more about lymphoma by carrying out tests on cells from B-cell lymphomas, including Hodgkin lymphomas and non-Hodgkin lymphomas. This could ultimately help to identify lymphoma characteristics that can help doctors make treatment choices. This research aims to:
- identify factors that can predict your prognosis (outcome)
- look at biomarkers (genetic changes) in people with chronic lymphocytic leukaemia (CLL) and monoclonal B-cell lymphocytosis (a low level of abnormal lymphocytes that can progress to CLL).
The researchers also want to collect information about the treatment participants have, and how well it works. The factors and biomarkers identified as potentially relevant to prognosis will be checked against how well treatment worked. This could help determine what treatment will work best for what person.
Samples are stored in the South Coast Tissue Bank (SCTB) in Southampton. The samples collected in the study could also be made available for other research. You are asked to consent to this when you consent to the study. Any research carried out using these samples is subject to a strict approval process.
What is involved
The trial team ask for tissue from a sample of your lymphoma biopsy done when you were first diagnosed. They will also ask your doctor to keep them informed about your treatment and progress.
Who can enter
Your consultant can give you advice on whether this study might be suitable for you.
The researchers need around 350 people for this study.
You may be able to enter if:
- You have chronic lymphocytic leukaemia or any mature B-cell lymphoma. People with monoclonal B-cell lymphocytosis can also enter.
- Your lymphoma is measurable by the tests used in the study.
- You are 18 or over.
You will not be able to enter if:
- Your medical history is not available.
- You are not able or willing to give consent to take part.