LYM1: a study to collect and test samples from different types of lymphoma and try to better understand how lymphomas develop and respond to treatment

There are no treatments in this study. The researchers need samples from people with B-cell lymphomas for research.


Purpose of study

The aim of the study is to create a tissue bank of samples from different types of B-cell lymphoma, which can be used to identify body substances that are measurable and can tell doctors who is likely to respond to treatment. These substances are known as ‘biomarkers’.

The researchers collect samples from people with chronic lymphocytic leukaemia (CLL), high grade B-cell lymphomas and low grade B-cell lymphomas at different stages of disease and treatment. They then screen all these samples for biomarkers. The researchers also collect clinical information so they can link treatment and outcome to the biomarkers.


What is involved

 You give a mouthwash sample to provide some DNA. Your doctor also asks your permission to send samples of:

  • blood
  • bone marrow
  • tumour tissue
  • any body fluids removed for testing, such as fluid that has collected around the lungs (pleural effusion) or in the abdomen (ascites).

You don’t have to give any extra samples or biopsies for the study. Your doctor sends samples from procedures and tests you are having as part of diagnosing and treating your lymphoma. Where possible, the researchers want samples:

  • when you are diagnosed
  • before you have treatment
  • every year after your diagnosis if your disease continues to grow or comes back
  • if you have a low grade lymphoma that transforms into a high grade type.

The researchers also ask your doctor to send information about the treatments you have and how well they work. The researchers link this to information on the biomarkers they find, to see if they can predict treatment response or outcome. All this information is kept confidential and no one can identify you from samples or records in the tissue bank.


Who can enter

Your consultant can give you advice on whether this trial might be suitable for you.

This is an ongoing tissue bank study so no specific number of samples are needed.

You may be able to enter if:

  • You have been diagnosed with any of the following:
    • chronic lymphocytic leukaemia
    • low-grade B-cell lymphoma
    • high-grade B-cell lymphoma.
  • You are over 18.

You will not be able to enter if:

  • You are not able to give consent for the study.