iPOLYMATH: a study to find out more about how B cells become cancerous and how the conditions the cells live in may contribute to that process

There is no change in standard treatment as part of this study. The researchers need permission to use a sample of your biopsy for research.

Purpose of study

The aim of the study is to find out more about how normal cells in lymph nodes and in tonsils can develop into lymphoma cells. The researchers want to find out what changes happen in normal B lymphocytes (B cells) when they turn into lymphoma cells. The researchers will find out more about how the lymphoma cells grow and how they are affected by what is immediately around them (their microenvironment). For example, they will look at how the lymphoma cells ‘talk’ to each other through interactions between the different cells’ proteins and explore ways of interrupting these cell conversations as a new way of treating lymphomas.

What is involved

If you are going to have a biopsy for suspected or confirmed B-cell lymphoma, the researchers will ask for permission to have a sample of the tissue removed by your surgeon for research. The researchers are collecting samples from people without lymphoma too, for example the tonsil tissue from people having tonsils removed.

Once the researchers have these samples, they study them in the laboratory to find out more about the factors that encourage normal cells to turn into lymphoma cells and the factors that encourage lymphoma cells to grow.

Finally, they intend to compare their findings to a library of lymphoma tumour tissue that already exists to see if they can find any similarity between their laboratory findings and animal studies and what happens when people develop a B-cell lymphoma.

Who can enter

Your consultant can give you advice on whether this study might be suitable for you.

Around 400 people are needed for this trial.

You may be able to enter if:

  • You are going to have or have had a lymph node removed because you have, or are suspected of having a B cell lymphoma.

You will not be able to enter if:

  • You are less than a month old.
  • You are a child and your parents do not give permission.